Where to eat between Charleston and Gatlinburg

This food trip itinerary gives you restaurant recommendations for places to eat over 2 days. Starting from Charleston, you can leave at 7:00 am and drive for about an hour to the first stop.

113 W Main St
Harleyville, SC
(843) 462-7499
$
  35 reviews
Bakeries, Delis
8am to 7pm
Day 1. Arrive at 8:00 am. Eat for about an hour. Then drive for about 20 minutes.
1427 Eutaw Rd
Holly Hill, SC
(803) 496-1227
$$
  135 reviews
Barbeque
11:30am to 8pm
Arrive at 9:20 am. Explore the area for about 2 hours. Double check the opening time of 11:30 am. Eat for about 2 hours. Then drive for about an hour.
1921 Airport Blvd
Cayce, SC
(803) 739-6520
$
  78 reviews
Mexican restaurants
9am to 8pm
Arrive at 2:50 pm. Eat for about 2 hours. Then drive for about 10 minutes.
940 Old Barnwell Rd
West Columbia, SC
(803) 951-0405
$$
  78 reviews
Burgers, American restaurants (New style), Sandwiches
11:30am to 5pm
Arrive at 5:00 pm. Eat for about 2 hours. Then drive for about an hour.
15835 Highway 221
Enoree, SC
(864) 969-6567
  2 reviews
Arrive at 8:30 pm. Eat for about an hour. Stay overnight. The next day, leave at 7:00 am. Then drive for about 20 minutes.
2960 Hwy 56
Pauline, SC
(864) 586-1148
Day 2. Arrive at 7:20 am. Eat for about 2 hours. Then drive for about 20 minutes.
930 E Main St
Spartanburg, SC
(864) 327-8228
$$
  343 reviews
Mexican restaurants
10am to 11pm
Arrive at 9:40 am. Wait for about 20 minutes. Double check the opening time of 10:00 am. Eat for about 2 hours. Then drive for about 20 minutes.
13241 Asheville Hwy
Inman, SC
(864) 708-1153
  8 reviews
Barbeque
6:30am to 10pm
Arrive at 12:20 pm. Eat for about 2 hours. Then drive for about an hour.
12 College St
Asheville, NC
(828) 255-4863
$$
Arrive at 3:30 pm. Eat for about 2 hours. Then drive for about 10 minutes.
626 Haywood Rd
Asheville, NC
(828) 252-0055
$$
Arrive at 5:30 pm. Eat for about 2 hours. Then drive for about an hour.

Reach your destination in Gatlinburg around 8:40 pm after eating at 10 restaurants over 2 days. If you were to drive nonstop, it would take about 5½ hours driving roughly 337 miles straight to Gatlinburg. Looking for more restaurants? You can choose a category below if you want to do an entire road trip full of Bakeries, Delis, Barbeque, Mexican restaurants, Burgers, American restaurants (New style), or more. Enjoy the journey!

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